Spotlight on Zyprexa for Mental and Mood Conditions
Published on May 20, 2021

Zyprexa, also known as Olanzapine, is a medication belonging to a classification of atypical antipsychotics. It is a newer-generation antipsychotic medication used to treat disorders such as schizophrenia, bipolar disorder, depression augmentation, and many other psychiatric disorders.

Zyprexa was first patented in 1971 and was FDA approved in 1996 for the treatment of schizophrenia. In 2009, Zyprexa was approved in the treatment of treatment-resistant depression, changing the way we treat depression, anxiety, and other disorders today. 

Zyprexa works differently than antidepressants in that it works on the dopamine system in the brain, as well as the serotonin system. Dopamine and Serotonin play a key role in learning, memory, and neurogenesis, which is the creation of new neurons. Studies have shown that things like chronic stress, aging, and viral infections can cause a decrease in the production of these neurons. Dopamine also helps to aid the flow of information to the brain regions responsible for thought and emotion.

Zyprexa is in a classification called a thienobenzodiazepine and works by blocking a receptor called the 5HT-2 (Serotonin) and D2 (Dopamine) receptor sites on the neurons in the brain. This works by preventing the reuptake of dopamine by the 5HT-2 and D2 receptor sites. This helps with a feeling of wellbeing, treatment of mania, as well as treatment of psychotic symptoms such as hallucinations, delusions, and feeling suspicious.

Although the name “antipsychotic” infers that it treats psychotic symptoms, however, these neurotransmitters play a key role in many mood disorders and can treat a myriad of symptoms associated with disorders such as depression, anxiety, and bipolar disorder. 

Although Zyprexa is a treatment for many, everyone’s brain chemistry is different and it may not be right for you. It may cause side effects or is not effective treatment of symptoms. If you try Zyprexa and find it’s not the best fit, don’t give up! There are several medications in this classification of medication that may be better suited to the chemistry of your brain.

Remember, if your treatment is not working effectively, be your own advocate and speak up! It might take a few tries to find your perfect fit. Make sure to speak with your provider about stopping Zyprexa. Do not try to stop Zyprexa alone, as stopping may cause symptoms to recur. You may need to try a different medication to treat your symptoms.

Do you feel better after starting Zyprexa? Don’t stop taking it! Continuing to take your medication as prescribed is imperative to help prevent relapse of symptoms!

Even though Zyprexa is a medication with an extremely intimidating name – remember back to the antipsychotic label? – it is an extremely effective medication with a generally tolerable side effect profile. Drowsiness, dizziness, appetite changes, or weight gain are some of the common side effects. However, they’re often better tolerated than some of it’s sister drugs like Risperidone or Haldol. These symptoms will often subside as you continue to take your medication regularly, but if these symptoms are intolerable or worsening over time, contact your provider. They will know the best suggestion to help you feel better!

Written by Nurse Audra, with guidance from Dr. Edwards

Source: Everyday Health